Table 1.
Omics analysis of ZDHHCs in gliomas
| Genes | RNA expression levels (tumor versus normal) | Protein expression levels (percent account for total included glioma cases) | Protein expression levels (normal cerebral cortex) | Methylation levels (IDH mutant versus wild type) | Mutation frequency |
|---|---|---|---|---|---|
| ZDHHC1 | no significance | not detected | not detected | hypermethylation | 0 |
| ZDHHC2 | upregulated | not detected: 50% low: 50% |
not detected | hypermethylation | 0.6% |
| ZDHHC3 | no significance | not detected: 25% low: 8% medium: 58% high: 9% |
medium | hypermethylation | 1.4% |
| ZDHHC4 | upregulated | not detected: 91% medium: 9% |
not detected | hypermethylation | 1.2% |
| ZDHHC5 | no significance | not detected: 25% low: 58% medium: 9% high: 8% |
low | hypermethylation | 0 |
| ZDHHC6 | no significance | not detected: 50% low: 17% medium: 33% |
not detected | hypermethylation | 1.7% |
| ZDHHC7 | no significance | not detected | not detected | hypermethylation | 0.2% |
| ZDHHC8 | no significance | not detected: 46% low: 54% |
not detected | hypermethylation | 0.6% |
| ZDHHC9 | upregulated | not detected: 36% low: 28% medium: 36% |
low | no significance | 1.4% |
| ZDHHC11 | downregulated | not detected: 100% | low | hypermethylation | 1.6% |
| ZDHHC12 | upregulated | low: 8% medium: 75% high: 17% |
medium | hypermethylation | 1% |
| ZDHHC13 | no significance | not detected: 84% low: 8% medium: 8% |
not detected | hypermethylation | 1.6% |
| ZDHHC14 | no significance | not detected: 20% low: 50% medium: 20% high: 10% |
medium | hypermethylation | 2.1% |
| ZDHHC15 | upregulated | not detected: 42% low: 42% medium: 16% |
not detected | no significance | 2.9% |
| ZDHHC16 | no significance | not detected | not detected | hypermethylation | 0.4% |
| ZDHHC17 | no significance | low: 18% medium: 73% high: 9% |
high | hypermethylation | 0.6% |
| ZDHHC18 | no significance | not detected: 27% low: 18% high: 55% |
not detected | hypermethylation | 0.2% |
| ZDHHC19 | no significance | not available | not available | hypermethylation | 2.9% |
| ZDHHC20 | no significance | not detected: 50% low: 42% medium: 8% |
not detected | no significance | 1.9% |
| ZDHHC21 | no significance | low: 8% medium: 50% high: 42% |
medium | hypomethylation | 2.3% |
| ZDHHC22 | upregulated in LGGs downregulated in GBM |
not available | not available | hypomethylation | 0.8% |
| ZDHHC23 | downregulated | not detected: 73% low: 18% medium: 9% |
medium | hypomethylation | 1.4% |
| ZDHHC24 | no significance | not detected: 58% low: 42% |
not detected | hypomethylation | 0 |