Table 1.

Eligibility criteria for the oncological genetic counseling

Personal history:

Male breast cancer

Woman with breast cancer and ovarian cancer

Woman with breast cancer <36 years

Woman with triple negative breast cancer <60 years

Woman with bilateral breast cancer <50 years

Woman with non-mucinous and non-borderline ovarian cancer at any age

Metastatic pancreatic adenocarcinoma

Metastatic prostate cancer

Personal history of breast cancer <50 years and first-degree familiaritya,bfor:

Breast cancer <50 years

Non-mucinous and non-borderline ovarian cancer at any age

Bilateral breast cancer

Male breast cancer

Locally advanced or metastatic pancreatic cancer

Metastatic prostate cancer

Personal history of breast cancer >50 years and family history of breast cancer, ovarian cancer, metastatic prostate cancer or locally advanced/metastatic pancreatic cancer in 2 or more first-degree relativesa,bamong them (including one in first degree with hera,b)

Personal history of prostate cancer and familiarityc:

At least one first-degree relativea with non-Grade Group 1 prostate cancer aged <60 years

At least two family members with non-Grade Group 1 prostate cancer aged <50 years

Family history of pancreatic cancer:

At least two first-degree relativesa with pancreatic adenocarcinomad

At least three family members with pancreatic adenocarcinomae

If present, testing eligibility criteria for genetic syndromes with an increased risk of pancreatic cancer

Family history of: Known pathogenic variant in a predisposing gene in a family member

^aFirst-degree relatives = parents, brothers/sisters, and children.

^bFor breast and ovarian cancers, on the paternal side of the family, also consider second-degree relatives (grandmother, aunts).

^cGrade Group 1 according to World Health Organization/International Society of Urological Pathology.

^dThe condition does not affect the situation in which both parents are/have been affected.

^eOn the same bloodline and with at least one first-degree relative.