FIGURE 3.

Growth is varied across indication categories. Trends in monthly approvals over time were analyzed in ICD-10 indication categories with >1,000 cumulative approvals (Supplementary Table S1). Approvals for pain (A); anxiety (B); sleep disorders (C); and PTSD (F) followed Negative binomial, 2nd degree polynomial curves (R² = 0.988, 0.989, 0.987, and 0.973, and Δm = 13,202.020, 1,413.481, 51.913, and 54.544, respectively). Approvals for cancer and related symptoms (D); and neuropathy (E) followed Negative binomial 4th degree polynomial curve (R² = 0.981 and 0.962, and Δm = 17.271 and 21.698, respectively). Approvals for epilepsy (G) moderately followed a Negative binomial 4th degree polynomial curve (R2 = 0.587, Δm = 7.922). Approvals for ASD (H) and convulsions (I) followed Negative binomial 3rd degree polynomial curves (R² = 0.977 and 0.918, and Δm = 27.715 and 31.812, respectively). Solid lines represent the best fit with shaded standard error of the mean.