Figure 2.

Long non coding RNA biogenesis and function. LncRNAs can be categorized into sense (A), antisense (B), bidirectional (C), intronic (D), and intergenic (E) lncRNAs based on their genomic location and Besides, some lncRNAs are reported to be transcribed from one of the strands of a DNA sequence. In addition to being transcribed by RNA polymerases, many of them are spliced, 5′ capped and polyadenylated. Although some lncRNAs can be translated into proteins, most of them serve as immediate regulators of genome function (e.g., microRNAs or very important binding partners of cellular components (e.g., proteins).