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. 2022 May 23;13:2853. doi: 10.1038/s41467-022-30304-9

Fig. 5. Dye@DIIIa exhibited improved pharmacokinetics compared with Dye@DIII and editable properties.

Fig. 5

a DIIIa was obtained using recombinant Pichia pastoris (pPIC9 strain). b Electrophoresis results for DIIIa and DIIIb. c NIR-II images of IR-783, ICG, and IR-780 complexed with DIII, DIIIa, or DIIIb. d–e NIR-II images of healthy mice injected with IR-783@DIIIa in lateral (f) and supine positions (e). Li Liver; Bl Bladder; Ki Kidneys. f Schematic figure of IR-783@DIIIa-TATE. g–h NIR-II images (g) and tumor-to-muscle ratio (h) of an AR42J tumor-bearing mouse injected with IR-783@DIIIa-TATE (n = 3). The red dotted squares were regions of interest (ROIs) of skin surrounding the tumor site, and the blue dotted circles were ROIs of tumor.