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. 2022 May 23;13:2853. doi: 10.1038/s41467-022-30304-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Schematic representation of TDIII expression using recombinant Pichia pastoris (pPIC9 strain). b Electrophoresis results of TDIII 1 (linkers: Leu-Glu) and TDIII 2 (linkers: -[Gly-Gly-Gly-Gly-Ser]₂-). c The tendencies of mixtures of dye and albumin, DIII, TDIII as the dye-to-protein molar ratio increased from 0.25:1 to 16:1. d Comparison of half-life for IR-783@TDIII and IR-783@HSA using Non-linear regression and two-phase exponential decay analysis. e–f High-magnification (2.5×) NIR-II images (e) and ROI analysis (f) of blood vessels under the skull of a shaved mouse injected with IR-783@TDIII. g–i High-magnification (2.5×) NIR-I and NIR-II images (g), cross-sectional intensity profiles (h), and ROI analysis (i) of a mouse suffering from congenital lymphedema injected with IR-783@TDIII. The white arrows indicate the tortuous lymphatic vessels surrounding the inguinal LN and the yellow arrow indicates the edematous LN. j High-magnification (2.5×) NIR-II image of a mouse bearing a PC3 tumor at 15 min p.i. of IR-783@TDIII. Source data are provided as a Source Data file.