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. 2022 May 23;13:2853. doi: 10.1038/s41467-022-30304-9

Fig. 7. Dye@TDIII facilitated high-quality imaging-guided surgery.

Fig. 7

a–c In vivo photostability of IR-783@HSA and IR-783@TDIII during continuous laser exposure. d Intraoperative navigation platform for imaging-guided surgery in small animals (n = 3). e, f Intraoperative NIR-II images of mice intratumorally injected with IR-783@TDIII before and after resection of metastatic tumor-adjacent LNs in the presence and absence of room lighting. g–j Bioluminescence and NIR-II images of mice bearing orthotopic breast tumors with metastasis in the axillary LNs. Bioluminescence imaging was used to monitor tumor progression and metastasis to the sentinel LNs. The yellow arrows indicate the metastatic LNs. NIR-II imaging-guided resection of the metastatic LNs was performed following injection of IR-783@TDIII and confirmed by 2D and 3D bioluminescence imaging. Bioluminescence imaging and H&E staining confirmed that the excised LNs were metastatic (j). Source data are provided as a Source Data file.