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. 2022 May 23;5:488. doi: 10.1038/s42003-022-03366-0

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Fig. 8 — Native MS confirms Leu-2 in the B pocket and Val-9 in the F pocket respectively as the main anchor positions of the pMHC. The analysis of truncated NV9 variants reveals that Val-2 is also a favored binding site. Moreover, Met-5 or Val-5, as well as Val-6, also contribute significantly to binding under certain circumstances. Among the anchor residues, Leu-2 contributes significantly more to the binding than Val-9. Concerning the termini, the N-terminus is of greater importance for binding than the C-terminus.