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. 2022 May 18;20:42–52. doi: 10.1016/j.bioactmat.2022.05.013

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — The effects of macrophage immune microenvironment on the immune function of fibroblasts. A) Leading terms analysis reveals the upregulation of granulocyte migration. B) Hub gene analysis reveals enrichment of various chemokines for innate immune. C) Leading terms analysis shows the most significant enrichment of regulation of innate immune response. D) Gene Set Enrichment Analysis (GSEA) analysis confirms the upregulated event of regulation of innate immune response. E) KEGG analysis reveals cytokine-related signaling pathway in M1 group. F) Hub gene analysis of the term of innate immune response. G) RT–qPCR confirms the upregulation of chemokines, inflammatory factors, and innate immune genes in M1 group. H) Leading term analysis reveals IFN, chemokines, TNF and IL-1 possibly contributed to fibroblasts' immune function in M1 group. I) Correlation analysis between up-regulated cytokines of M1 immune microenvironment and up-regulated immune-related genes of fibroblast. Data are presented as means ± SD; *p < 0.05.