Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 May 18;20:42–52. doi: 10.1016/j.bioactmat.2022.05.013

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Scheme 1 — Experimental flow of this study. A) Inducing macrophages towards M1 and M2 phenotypes; B) Dissecting the multifaceted effects of M1 and M2 macrophages from the aspect of metal soft tissue integration; C) Analyzing different regulatory effects of macrophage-derived immune microenvironments on human gingival fibroblasts on titanium surfaces: a) the cell adhesion behaviors alterations and their potential mechanisms were evaluated using enrichment analysis, cell adhesion assay, RT–qPCR, immunofluorescence, and correlation analysis; b) the fiber synthesis function of fibroblasts and their potential mechanisms were evaluated using enrichment analysis, Sirius red staining, RT–qPCR, immunofluorescence, and correlation analysis; c) the tissue contraction function of fibroblasts and their potential mechanisms were evaluated using enrichment analysis, collagen gel assay, RT–qPCR, immunofluorescence, and correlation analysis; d) the immune regulatory function of fibroblasts and their potential mechanisms were evaluated using enrichment analysis, RT–qPCR, and correlation analysis.