FIGURE 4.

Quantification of contraction rate for patient and control cell lines (A) Contraction rate was calculated by the distance between mid-points of the intersection of 60% peak strain and average contractile strain plots and converted to beats per minute. (B) Overlaid histograms of the contraction rate for all samples of blue (control) and patient (red) cell lines. (C) Rate of spontaneous contraction across all samples is significantly slower in the patient line than the control p < 0.0001.