Table 2.
CpGs Associated with POAF.
| CpG | Methylation | Nearest Gene | Location | Discovery P-value | Discovery FDR | Validation P-value |
|---|---|---|---|---|---|---|
| chr4:62623910 | Hypo | ADGRL3-AS1 | Upstream | 2.57E-08 | 8.16E-03 | |
| chr6:33576278 | Hyper | BAK1 | Intron | 2.53E-09 | 1.61E-03 | |
| chr9:128263479 | Hyper | GOLGA2 | Intron | 1.50E-09 | 1.27E-03 | |
| chr15:75632860 | Hyper | IMP3 | Downstream | 1.13E-08 | 4.11E-03 | |
| chr16:24640902 | Hyper | TNRC6A | Exon | 4.11E-08 | 1.01E-02 | 0.026 |
| chr16:27841320 | Hyper | GSG1L | Intron | 9.28E-09 | 3.93E-03 | |
| chr16:33770791 | Hypo | LOC390705 | Upstream | 6.63E-10 | 8.42E-04 | 0.054 |
| chr17:20376849 | Hypo | CCDC144CP | Intron | 4.91E-08 | 1.01E-02 | 0.226 |
| chr17:20376904 | Hypo | CCDC144CP | Intron | 3.40E-08 | 9.59E-03 | 0.690 |
| chr17:20376906 | Hypo | CCDC144CP | Intron | 3.58E-10 | 8.42E-04 | 0.624 |
| chr21:8257115 | Hyper | CBS | Intron | 4.25E-09 | 2.16E-03 | |
| chr21:44932986 | Hyper | LINC01547 | Exon | 4.55E-08 | 1.01E-02 | 0.078 |
Twelve CpGs have p-values <5 × 10−8 in the discovery cohort after controlling for clinical and methylation covariates. The CpG methylation status associated with POAF, nearest gene, CpG location relative to the nearest gene and the statistical significance of these loci in the validation cohort are also listed. The methylation status of six CpGs in the validation cohort were unable to be measured using the targeted bisulfite sequencing approach. One CpG, chr16:24640902, was successfully validated in a separate cohort.