TABLE 1.

A list of genes associated with various forms of CLN. Please add a reference column.

Human Disease	Gene	Protein	Protein Localization	Protein Function
CLN1	PPT1 Vesa et al. (1995)	Palmitoyl-protein thioesterase 1	Lysosome	Protein localization regulation Gorenberg et al. (2021)
CLN2	TPP1 Sleat et al. (1997)	Tripeptidyl-peptidase 1	Lysosome	Lysosomal protease Lin et al. (2001)
CLN3	CLN3 Mitchison et al. (1997)	Battenin	Endolysosome	Lysosomal acidification Pearce et al. (1999)
CLN4	DNAJC5 Nosková et al. (2011)	CSPα/DNAJC5	Endolysosome	Co-chaperone Braun et al. (1996)
CLN5	CLN5 Savukoski et al. (1998)	CLN5	Lysosome	Lysosome to TGN trafficking Mamo et al. (2012)
CLN6	CLN6 Gao et al. (2002)	CLN6	ER	Cargo trafficking Bajaj et al. (2020)
CLN7	MFSD8 Siintola et al. (2007)	MFSD8	Lysosome	Transporter Sharifi et al. (2010)
CLN8	CLN8 Ranta et al. (1999)	CLN8	ER	Cargo trafficking di Ronza et al. (2018)
CLN10	CTSD Siintola et al. (2006)	Cathepsin D	Lysosome	Lysosomal protease Cullen et al. (2009)
CLN11	GRN Smith et al. (2012)	Granulin	Lysosome	Lysosomal regulation Kao et al. (2017)
CLN12	ATP13A2 Bras et al., (2012)	ATP13A2	Endolysosome	Polyamine transporter van Veen et al. (2020)
CLN13	CTSF Smith et al., (2013)	Cathepsin F	Lysosome	Lysosomal protease Shi et al. (2000)
CLN14	KCTD7 Staropoli et al., (2012)	KCTD7	Cytosol	Unknown