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. 2022 May 10;12:880636. doi: 10.3389/fcimb.2022.880636

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Copyright © 2022 Wu, Jian, Tang, Liu, Liu, Liu and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune annotation and correlation between HP infection and anti-PD-1/L1, anti-CTLA-4 immunotherapy. (A) Immune cell-infiltrating characteristics of high- and low-risk groups and their correlation with risk signature. (B) Relations between tumor purity, ESTIMATE score, immune score, stromal score, and different STAD phenotypes. (C) Correlation between the abundance of immune cells and three candidate genes. (D) Box plot suggesting the difference of response towards immunotherapy between high- and low-risk score group. (E) Violin plot illustrating the result of ESTIMATE analysis. (F) Relationships between the risk signature and cancer stem cell (CSC) index. (G–I) Expression of PD-1, CTLA-4, PD-L1 in low- and high-risk score groups, respectively. ns, no significance, p≥0.05; *, p< 0.05; **, p<0.01; ***, p<0.001.