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. 2022 May 10;13:894518. doi: 10.3389/fphys.2022.894518

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Copyright © 2022 Kleene.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model of Ca²⁺ signaling and amplification in renal primary cilium. PC2 and TRPV4, but not TRPM4, can conduct Ca²⁺ into the cilium. An increase in intraciliary Ca²⁺ can further activate all three of the channel types.