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. 2022 Apr 25;298(6):101982. doi: 10.1016/j.jbc.2022.101982

Figure 5.

Figure 5

Compounds identified from the screen show efficacy in improving Fxn levels in doxorubicin-treated cardiomyocytes.A, H9C2 rat cardiomyocytes were cultured in the presence of doxorubicin and 10 to 100 μM DBM for 48 h and Fxn and GAPDH levels determined by Western blot. A representative blot is shown. Quantification of three biologic replicate experiments is shown. B, quantification of changes in response to other top compounds from the screen are shown (n = 3 replicate experiments). DBM, dibenzoylmethane; Fxn, frataxin.