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. 2022 Apr 20;298(6):101966. doi: 10.1016/j.jbc.2022.101966

Figure 2.

Figure 2

miR-141/200c deficiency leads to reduced lipid accumulation in response to ethanol feeding in liver.A, different TG species were examined in livers of WT-EB and KO-EB by metabolomics and lipidomics analyses (n=7–8). B, PLSDA diagram of metabolomics and lipidomics analysis. Liver samples from WT-EB and KO-EB. C, different species of fatty acids analyzed by metabolomics in livers of WT-EB and KO-EB. D, plasma lipid profiles analyzed by FPLC from WT- and KO-fed CB or EB. E, quantification of TGs in plasma lipid profiles in (D) is shown. Data are presented as mean ± SEM. Statistical significance was assessed by Student’s t test; ∗p < 0.05. PLSDA, Partial least squares discriminant analysis; FPLC, fast protein liquid chromatography; CB, LDC without ethanol supplementation plus maltose dextrin binge; EB, LDC supplemented with ethanol plus ethanol binge; TG, triglyceride.