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. 2022 Apr 20;298(6):101966. doi: 10.1016/j.jbc.2022.101966

Figure 6.

Figure 6

miR-141/200c deficiency normalizes ethanol-mediated reduction of hepatic TG secretion and PC abundance.A, Western blot of protein prepared from WT- and KO-mice–fed CB or EB. B, different species of PCs measured by lipidomics analysis. C, mRNA expression levels of genes were measured by qPCR in mouse livers and normalized to Rpl32 or Hprt (n=6–8). D, TG secretion rates were analyzed over a 4 h period after intravenous injection of Triton WR-1339 (500 mg/kg BW) in WT- and KO-fed CB or EB (n=4–8). Data are presented as mean ± SEM. Statistical significance was assessed by Student’s t test; ∗p < 0.05 (B). ∗p < 0.05, WT-CB versus WT-EB (C and D); ǂ, p < 0.05, WT-EB versus KO-EB (C and D). BW, body weight; CB, LDC without ethanol supplementation plus maltose dextrin binge; EB, LDC supplemented with ethanol plus ethanol binge; PC, phosphatidylcholine; TG, triglyceride.