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. 2022 May 17;15:100294. doi: 10.1016/j.mtbio.2022.100294

Fig. 5.

Fig. 5

M@NPs/miR365 effectively improved the therapeutic effect of tumor. A) Timeline of animal experiment. B) Representative ex vivo fluorescence image of tumor after intravenous injection of NPs/NC (PCP with negative control miRNA), DirM (Dir near-infrared fluorescent labeled cell membrane), NPs/cy5 (PCP with Cy5 fluorescent labeled miR365) and DirM@NPs/cy5 (DirM encapsulated NPs/cy5) (n ​= ​4). C) Tumor size. D) Weight statistics of tumor tissue (n ​= ​6). E) Representative photos of H&E staining of tumor tissue. F) Immunofluorescence staining of Bcl2 and Ki67 in tumor tissues. G-H) Quantitative analysis of Ki67 and Bcl2 fluorescence (n ​= ​4). n. s (no significance). ∗P ​< ​0.05, ∗∗∗P ​< ​0.001.