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. 2022 May 17;15:100294. doi: 10.1016/j.mtbio.2022.100294

Scheme 1.

Scheme 1

Schematically describe the synthesis of M@NPs and the application of M@NPs/miR365 in colon cancer therapy. A) Positively charged PCP and negatively charged miRNA mimic self assembled into NPs. B) The cancer cell membrane fragments prepared by ultrasonic crushing method was encapsulated onto NPs to form M@NPs. C) M@NPs reach the tumor site after caudal vein injection to realize target gene therapy in tumor tissue. D) The molecular mechanism of tumor therapy of M@NPs.