Table 4.
Adverse events of CoronaVac vaccination in primary antiphospholipid syndrome patients and controls.
| After vaccine 1st dose | After vaccine 2nd dose | |||||
|---|---|---|---|---|---|---|
| PAPS (n=44) | Controls (n=132) | p-Value | PAPS (n=44) | Controls (n=132) | p-Value | |
| No symptoms | 26 (59.1) | 81 (61.4) | 0.789 | 25 (59.5) | 86 (66.7) | 0.400 |
| Local reactions (at the injection site) | 14 (31.8) | 27 (20.5) | 0.123 | 8 (19.0) | 26 (20.2) | 0.876 |
| Pain | 12 (27.3) | 22 (16.7) | 0.123 | 6 (14.3) | 25 (19.4) | 0.457 |
| Erythema | 5 (11.4) | 1 (0.8) | 0.004 | 2 (4.8) | 1 (0.8) | 0.150 |
| Swelling | 2 (4.5) | 5 (3.8) | >0.999 | 3 (7.1) | 8 (6.2) | 0.732 |
| Bruise | 6 (13.6) | 4 (3.0) | 0.017 | 0 (0) | 1 (0.8) | >0.999 |
| Pruritus | 2 (4.5) | 1 (0.8) | 0.155 | 2 (4.8) | 6 (4.7) | >0.999 |
| Induration | 4 (9.1) | 6 (4.5) | 0.270 | 2 (4.8) | 9 (7.0) | >0.999 |
| Systemic reactions | 16 (36.4) | 39 (29.5) | 0.398 | 15 (35.7) | 37 (28.7) | 0.390 |
| Fever | 2 (4.5) | 2 (1.5) | 0.260 | 2 (4.8) | 3 (2.3) | 0.597 |
| Malaise | 6 (13.6) | 5 (3.8) | 0.019 | 3 (7.1) | 13 (10.1) | 0.764 |
| Somnolence | 6 (13.6) | 10 (7.6) | 0.226 | 1 (2.4) | 9 (7.0) | 0.454 |
| Lack of appetite | 2 (4.5) | 4 (3.0) | 0.641 | 1 (2.4) | 6 (4.7) | >0.999 |
| Nausea | 6 (13.6) | 1 (0.8) | 0.001 | 3 (7.1) | 9 (7.0) | >0.999 |
| Vomit | 1 (2.3) | 1 (0.8) | 0.439 | 0 (0) | 1 (0.8) | >0.999 |
| Diarrhea | 4 (9.1) | 7 (5.3) | 0.471 | 3 (7.1) | 7 (5.4) | 0.709 |
| Abdominal pain | 3 (6.8) | 6 (4.5) | 0.693 | 3 (7.1) | 7 (5.4) | 0.709 |
| Vertigo | 5 (11.4) | 3 (2.3) | 0.024 | 2 (4.8) | 6 (4.7) | >0.999 |
| Tremor | 3 (6.8) | 0 (0) | 0.015 | 1 (2.4) | 2 (1.6) | 0.573 |
| Headache | 6 (13.6) | 16 (12.1) | 0.792 | 8 (19.0) | 23 (17.8) | 0.859 |
| Fatigue | 8 (18.2) | 5 (3.8) | 0.002 | 5 (11.9) | 14 (10.9) | 0.851 |
| Sweating | 4 (9.1) | 2 (1.5) | 0.035 | 3 (7.1) | 3 (2.3) | 0.159 |
| Myalgia | 4 (9.1) | 3 (2.3) | 0.067 | 6 (14.3) | 14 (10.9) | 0.548 |
| Muscle weakness | 5 (11.4) | 4 (3.0) | 0.044 | 5 (11.9) | 10 (7.8) | 0.409 |
| Arthralgia | 6 (13.6) | 5 (3.8) | 0.019 | 4 (9.5) | 9 (7.0) | 0.737 |
| Back pain | 7 (15.9) | 7 (5.3) | 0.024 | 3 (7.1) | 16 (12.4) | 0.413 |
| Cough | 4 (9.1) | 4 (3.0) | 0.109 | 0 (0) | 6 (4.7) | 0.338 |
| Sneezing | 4 (9.1) | 6 (4.5) | 0.270 | 5 (11.9) | 11 (8.5) | 0.514 |
| Coryza | 3 (6.8) | 11 (8.3) | >0.999 | 5 (11.9) | 16 (12.4) | 0.932 |
| Stuffy nose | 6 (13.6) | 6 (4.5) | 0.038 | 2 (4.8) | 12 (9.3) | 0.522 |
| Sore throat | 0 (0) | 5 (3.8) | 0.333 | 2 (4.8) | 7 (5.4) | >0.999 |
| Shortness of breath | 2 (4.5) | 4 (3.0) | 0.641 | 0 (0) | 4 (3.1) | 0.573 |
| Conjunctivitis | 0 (0) | 0 (0) | - | 0 (0) | 1 (0.8) | >0.999 |
| Pruritus | 2 (4.5) | 0 (0) | 0.061 | 2 (4.8) | 2 (1.6) | 0.253 |
| Skin rash | 1 (2.3) | 2 (1.5) | >0.999 | 0 (0) | 1 (0.8) | >0.999 |
Results are presented in n (%). PAPS—primary antiphospholipid syndrome.