Figure 3.

Association between viruses and tumor types in 48,148 tumors. A: Forest plot demonstrating the virus-tumor type relationships that are enriched with statistical significance (P < 0.005), the cutoff was determined for Bonferroni adjustment given multiple hypotheses for each tumor type. Error bars show the 95% CI. Associations are arranged by virus. Associations in bold and labeled with asterisk are novel associations. B: Scatterplot showing the virus reads of human herpes virus 6 (HHV6) in tumor (y axis) compared with peripheral blood (x axis). The light blue triangles indicate samples that have virus detected only in tumor but not in blood. Both axes are log10 transformed. C: Bar chart showing the frequency of HHV6 detected in different tumor types and proportion of cases that are chromosomally integrated (ciHHV6) versus tumor only (somatic). Neuroblastoma is the only tumor type that is statistically enriched for HHV6, and the enrichment is from samples with HHV6 in tumor-only samples.