Figure 5.

Analysis of virus integration identified by MSK-IMPACT. A: Bar plot showing the distribution of tumor types and viruses in which viral integration was detected. B: Genome browser view showing integration of human papilloma virus 16 (HPV16) within ERBB2 gene. The internal panel shows the whole genome log-ratio plot for the tumor, demonstrating 13-fold amplification of ERBB2 associated with the HPV16 integration, highlighted by the green circle. C: Oncoprint of hepatocellular carcinoma cases from cohort, demonstrating mutual exclusivity between hepatitis B virus integration and TERT mutations. EBV, Epstein-Barr virus.