Figure 8.

Antiviral activities of selected compounds in MRC-5 cells in vitro. (A) Favipiravir (used as known reference control), (B) Acarbose, (C) Darunavir, (D) FAD hydrate, (E) GRL0617, (F) Lactitol, (G) Lopinavir, (H) Mefloquine, (I) Oxidized L-Glutathione, (J) Ritonavir, and (K) Rutintrihydrate were incubated with MRC-5 cells at the indicated concentrations for 6 days at 37°C in a CO₂ incubator and the antiviral activities of the compounds represented as the percentage of cells protected from virus-induced CPE was analysed quantitatively by the colorimetric MTT assay as described in Methods. The raw data was converted to % cell viability and plotted against the indicated doses. Experimental data sets were modeled using a logistic regression model and the 50% effective concentrations (EC₅₀) were derived (Supplementary Table 4).