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. Author manuscript; available in PMC: 2022 May 24.
Published in final edited form as: Nat Protoc. 2021 Jan 18;16(2):1219–1250. doi: 10.1038/s41596-020-00456-3

Fig. 6 |. Schematic of the steps involved in processing and scoring high-throughput trigenic interaction screens using τ-SGA scoring pipeline.

Fig. 6 |

Sequential stages of the main script trigenic_scoring_job.m, which defines parameters and then invokes compute_sgascore.m to generate and output SGA scores. Using these SGA scores and an assignment file designed for the specific query screens in the dataset, the script then computes the τ-SGA trigenic interaction scores. It should be noted that the trigenic scoring equation used in Stage 4 is slightly different from the one in Fig. 1, and the former can be directly derived from the latter as shown previously9.