Skip to main content
. Author manuscript; available in PMC: 2022 May 24.
Published in final edited form as: Acc Chem Res. 2021 Oct 22;54(21):4012–4023. doi: 10.1021/acs.accounts.1c00521

Figure 1.

Figure 1.

(a) Schematic of the domain organization of RIG-I and MDA5. (b) Top and side views of MDA5 (without 2CARDs): 12 bp dsRNA complex structure in the presence of the ADP analogue ADPNP. (c) Structures of MAVS CARD filament nucleated by RIG-I 2CARD oligomers. 2D and 3D models are shown on the right. (d) Cartoon model of filamentous RLRs nucleating MAVS to form filaments to activate downstream factors for IFN signaling. (b) Reprinted with permission from ref 1. Copyright 2013 Elsevier Inc. (c, d) Reprinted with permission from ref 2. Copyright 2014 Elsevier Inc.