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. Author manuscript; available in PMC: 2022 May 24.
Published in final edited form as: Acc Chem Res. 2021 Oct 22;54(21):4012–4023. doi: 10.1021/acs.accounts.1c00521

Figure 2.

Figure 2.

(a) View of UUU recognized by Macaca mulatta TLR7 (MmTLR7). (b) View of U recognized by human TLR8 (hTLR8). The structural formulas of uridine are highlighted to the right of each panel, and interacting atoms in the uracil base are indicated by arrows. (c) Structures of unmodified uridine, cytidine, and adenosine and their chemically modified versions. The carbon and nitrogen atoms in the base ring are numbered in red. The carbon atoms in the ribose ring are numbered in green and labeled with a prime (′). (a) Reprinted with permission from ref 33. Copyright 2016 Elsevier Inc. (b) Reprinted with permission from ref 34. Copyright 2015 Nature Publishing Group.