Table 2.
Maximum and timing of log10 parasite killa.
| Treatment | Measure | Cohort Geometric mean (90% confidence interval)b |
||
|---|---|---|---|---|
| SJ733 600 mg × 1 | SJ733 300 mg × 3 | SJ733 600 mg × 3 | ||
| SJ733 | Max Log10 Kill | 2·6 (2·3, 2·8) | 6·9 (6·3, 7·4) | 8·7 (8·2, 9·2) |
| Time to Max Kill (h) | 36·2 (34·7, 37·7) | 90·0 (79·4, 100·5) | 105·4 (91·2, 119·6) | |
| SJ733 + Cobicistat | Max Log10 Kill | 6·9 (6·4, 7·3) | 11·9 (11·2, 12·6) | 13·2 (12·5, 14·0) |
| Time to Max Kill (h) | 75·9 h (70·1, 81·7) | 121·9 (111·8, 132·0) | 133·6 (122·3, 144·9) | |
a
These results are predictions based on the pharmacokinetic and pharmacodynamic model.
b
Variability considered interindividual heterogeneity but excluded intraindividual heterogeneity and the breadth of potential SJ733+cobicistat pharmacokinetic profiles (i.e., only maximum decline was used).