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. 2022 May 10;16:852741. doi: 10.3389/fnins.2022.852741

TABLE 6.

Overview of all polysomnography-related data required to evaluate the pre-defined hypotheses that were based on the reported results in the study of Rojc et al. (2014).

Non-imputed data

pNAMB NBR HAMB HBR

(n = 8) Night 1
(n = 8)
Night 10
(n = 7)
Night 1
(n = 10)
Night 10
(n = 8)
Night 1
(n = 11)
Night 10
(n = 10)
M ± SD M ± SD M ± SD M ± SD M ± SD M ± SD M ± SD
Hypothesis 1; the acute effect of hypoxia on sleep architecture
 N2 (min) 160 ± 52 191 ± 52 181 ± 58
 N3 (min) 104 ± 23 73 ± 26 78 ± 37
Hypothesis 2; the effect of sustained hypoxic exposure on sleep architecture
 N1 (min) 42 ± 21 79 ± 58 63 ± 38
 N3 (min) l104 ± 23 77 ± 28 88 ± 25
Hypothesis 3; the effect of BR on the number of awakenings
 Arousals (# of events) ^° 67 ± 31 76 ± 48 205 ± 128 181 ± 119
Hypothesis 4; the effect of sustained BR on the number of awakenings
 Arousals (# of events)° 67 ± 31 71 ± 38 221 ± 119

Imputed data

pNAMB NBR HAMB HBR

(n = 12) Night 1
(n = 12)
Night 10
(n = 12)
Night 1
(n = 12)
Night 10
(n = 12)
Night 1
(n = 12)
Night 10
(n = 12)
M ± SD M ± SD M ± SD M ± SD M ± SD M ± SD M ± SD

Hypothesis 1; the acute effect of hypoxia on sleep architecture
 N2 (min) 163 ± 42 189 ± 47 181 ± 55
 N3 (min) ^° 97 ± 22 73 ± 23 79 ± 36
Hypothesis 2; the effect of sustained hypoxic exposure on sleep architecture
 N1 (min) ^ 47 ± 20 88 ± 50 66 ± 35
 N3 (min) ^ 97 ± 22 78 ± 24 91 ± 23
Hypothesis 3; the effect of BR on the number of awakenings
 Arousals (# of events) ^° 73 ± 28 92 ± 45 214 ± 118 181 ± 113
Hypothesis 4; the effect of sustained BR on the number of awakenings
 Arousals (# of events)° 73 ± 28 71 ± 28 208 ± 113

Mean (M) and standard deviation (SD) are depicted for both the data set with- and the data set without imputed data.

+Indicates a significant difference between pNAMB and NBR, ^indicates a significant difference between pNAMB and HAMB, °indicates a significant difference between pNAMB and HBR; pNAMB, pseudo normobaric normoxic ambulatory; NBR, normobaric normoxic bed rest; HAMB, normobaric hypoxic ambulatory; HBR, normobaric hypoxic bed rest; Arousals, total number of arousals.