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. 2022 May 11;4(3):fcac120. doi: 10.1093/braincomms/fcac120

Figure 4.

Figure 4

Analysis of App processing genes in the Abca7 KO mouse brain. (A) mRNA expression of Adam10, Bace1, Psen1 and Psen2 in male Abca7 KO (n = 10 or 31) versus WT (n = 10 or 11) and female Abca7 KO (n = 10 or 21) versus WT (n = 10 or 24); t-test, **P < 0.005 t = 3.089. (B) Protein expression of Psen1 in male Abca7 KO (n = 10) versus WT (n = 9) mice and optical density (OD) measurement of the protein bands normalized to β-actin; t-test, *P < 0.05 t = 2.148. (C) Protein expression of Psen1 in female Abca7 KO (n = 9) versus WT (n = 9) mice and OD measurement of the protein bands normalized to β-actin; t-test, not significant.