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. 2022 May 11;4(3):fcac120. doi: 10.1093/braincomms/fcac120

Figure 5.

Figure 5

Sex-specific impact of Abca7 deletion on brain cholesterol. (A) FC levels, as measured by enzymatic assay, in male Abca7 KO (n = 21) versus WT (n = 11) and female Abca7 KO (n = 21) versus WT (n = 11); t-test, *P < 0.05 t = 2.189. Each data point represents one animal. (B) FC levels, as measured by TLC, in male Abca7 KO (n = 10) versus WT (n = 9) and female Abca7 KO (n = 10) versus WT (n = 9) and optical density (OD) measurement of the FC staining; t-test, **P < 0.005 t = 3.256. Each data point represents one animal. (C) Transcription of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) mRNA in male Abca7 KO (n = 31) versus WT (n = 11) and female Abca7 KO (n = 21) versus WT (n = 24); t-test, *P < 0.05 t = 2.014. Each data point represents one animal. (D) Correlation of FC and amyloid-β42 in male (n = 30) and female (n = 31) mouse brain. (E) Correlation of FC and amyloid-β40 in male (n = 31) and female (n = 32) mouse brain.