Table 3: Current Approved Direct Oral Anticoagulant Regimens for Venous Thromboembolism Prophylaxis after Major Orthopaedic Surgery.

DOACs	Indications	Recommended Dose	Recommended Duration	Approved by
Dabigatran	VTE prophylaxis after major orthopaedic surgery	150–220 mg once daily	THA 28–35 days TKA (10 days)	ACCP (2012),[15] NICE (2019),[16] ASH (2019),[17] SIGN (2010)[18]
Rivaroxaban	VTE prophylaxis after major orthopaedic surgery	10 mg once daily	THA 28–35 days TKA (10–14 days)	ACCP (2012),[15] NICE (2019),[16] ASH (2019),[17] SIGN (2010)[18]
Apixaban	VTE prophylaxis after major orthopaedic surgery	2.5 mg twice daily	THA 32–38 days TKA (10–14 days)	ACCP (2012),[15] NICE (2019),[16] ASH (2019)[17]
Edoxaban	VTE prophylaxis after major orthopaedic surgery	30 mg once daily		Japanese guidelines[75]

ACCP = American College of Chest Physicians; ASH = American Society of Hematology; DOAC = direct oral anticoagulants; NICE = National Institute for Health and Care Excellence; SIGN = Scottish Intercollegiate Guidelines Network; THA = total hip arthroplasty; TKA = total knee arthroplasty; VTE = venous thromboembolism.