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. Author manuscript; available in PMC: 2022 May 24.
Published in final edited form as: Cell Rep. 2022 May 3;39(5):110779. doi: 10.1016/j.celrep.2022.110779

Figure 1. Microscopic tumors initiated by activation of upstream Hh signaling fail to progress.

Figure 1.

(A) Histology of hair follicle (HF)-associated GP tumors, 5–17 weeks post-TAM. Right photo shows shaved dorsal skin devoid of palpable tumors, 17 weeks post-TAM.

(B) Quantitation of HF-associated tumor area.

(C) Histology of touch dome (TD)-derived GP tumors (arrow), 5–17 weeks post-TAM. Right photo shows view of small TD papules, ~1 mm diameter.

(D) Quantitation of TD-derived tumor area, in arbitrary pixel units per cm.

(E) Histology of HF-derived LP tumors, 5–17 weeks post-TAM.

(F) Quantitation of LP tumors.

(G) Histology of microscopic HF-associated SmoM2 tumors arising from Lrig1+ stem cells (left, 15 weeks post-TAM) or Gli1+ stem cells (right, 20 weeks post-TAM).

(H) Schematic of GP tumor kinetics.

Data are represented as mean ± SEM, with significance calculated by one-way ANOVA. **p < 0.01. Scale bars, 50 μm. Blue scale bar, 1 mm.