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. Author manuscript; available in PMC: 2022 May 24.
Published in final edited form as: Cell Rep. 2022 May 3;39(5):110779. doi: 10.1016/j.celrep.2022.110779

Figure 4. p53-deficient microscopic tumors largely do not progress.

Figure 4.

(A) Peripheral basal tumor cells express p53 (green) in GP mice, 5–17 weeks post-TAM.

(B) Basal matrix progenitors directly abutting the dermal papilla (dotted) also express p53 (green) in the growing hair follicle.

(C) Quantitation for p53 in GP basal and suprabasal tumor compartments, 5–17 weeks post-TAM.

(D) Histology of HF-derived GP tumors that are either p53-heterozygous (GPP53-Het) or deleted (GPP53-KO), 5–17 weeks post-TAM. Right panels, validation of p53 loss (green) in GPP53-KO tumors, 17 weeks post-TAM.

(E) Quantitation of GPP53-Het and GPP53-KO tumor area.

(F) Quantitation of GPP53-Het and GPP53-KO tumor proliferation.

(G) Photo and histology of GPP53-KO macroscopic tumors.

Data are represented as mean ± SEM, with significance calculated by one-way ANOVA. Significance for beeswarm plots was calculated using a linear mixed model. **p < 0.01; ***p < 0.001. Scale bars, 50 μm. Ruler marks, 1 mm. See also Table S1 for animal numbers.