Fig. 1. (A) Structure of compounds 1 and 2; (B) cytotoxicity data for Alamar blue assay (IC50) were transformed, X = log(10), normalized between 0% and 100% and fitted with sigmoidal dose–response curves; (C) anti-plasmodial activity of compounds against ART-resistant strain, data (relative SYBR green-1 fluorescence) were transformed, X = log(10), normalized between 0% and 100% and fitted with sigmoidal dose–response curves. DHA – dihydroartemisinin, CQ – chloroquine.
