ADME profile of compounds^a.

SN	log P	TPSA	GI Abs	BBB permeability	Metabolism at the site of CYP450					Lip. vio	TOX
					1A2	C19	2C9	3A4	2D6
1	3.29	65.04	High	Yes	No	No	No	0.43	0.22	0	0.76
2	6.11	94.88	High	No	No	Yes	No	0.91	0.01	1	0.82

^alog P is the logarithm of the octanol–water partition coefficient; TPSA: total polar surface area; GI abs: gastrointestinal absorption; BBP: blood–brain barrier permeability; metabolism CYP450: the probability of metabolism on site of cytochrome-450; lip. vio: total number of violations of lipinski rule of five; tox: the probability of maximum toxicity of the compounds.