List of molecular docking based generated outcomes of compounds (1 and 2) against studied proteins. Binding energy (BE, kcal mol⁻¹) and inhibition constant (IC)^a.

Target proteins	Compound 1			Compound 2
	Selected pose	BE	IC	Selected pose	BE	IC
GST	30	−3.77	1.72 mM	9	−1.69	57.82 mM
CYB	19	−2.75	9.68 mM	33	−1.3	111.76 mM
MPEXP	19	−4.63	401.46 μM	27	−5.47	98.28 μM
PLM	41	−7.56	10.55 μM	39	−8.49	600.03 nM
DPS	35	−4.22	805.09 μM	26	−4.7	358.79 μM
CDK	40	−6.77	10.94 μM	3	−5.47	97.91 μM
GR	43	−4.05	1.07 mM	23	−2.56	13.18 mM
DOD	26	−5.52	89 μM	27	12.54	N/A
FR	3	−3.96	1.25 mM	25	−4.25	768.57 μM
DRTS	6	−5.99	40.75 μM	2	−2.64	11.7 mM

^aGST – glutathione S-transferase Q8MU52; CYB – cytochrome b Q02768; MPEXP – malaria protein EXP-1 P04926; PLM – plasmepsin-II P46925; DPS – dihydropteroate synthetase Q27738; CDK – calcium-dependent protein kinase 1 P62344; GR – glutathione reductase Q94655; DOD – dihydroorotate dehydrogenase (quinone), mitochondrial Q08210; FR – ferredoxin-NADP reductase, apicoplast C6KT68; DRTS – bifunctional dihydrofolate reductase-thymidylate synthase P13922.