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. 2022 May 9;24(5):e32006. doi: 10.2196/32006

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©Nicola Coley, Laurine Andre, Marieke P Hoevenaar-Blom, Tiia Ngandu, Cathrien Beishuizen, Mariagnese Barbera, Lennard van Wanrooij, Miia Kivipelto, Hilkka Soininen, Willem van Gool, Carol Brayne, Eric Moll van Charante, Edo Richard, Sandrine Andrieu, HATICE study group, PRODEMOS study group. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 09.05.2022.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.

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Adjusted mean difference in 18-month changes in outcome measures in low, moderate, and high engagement categories in the HATICE intervention group compared with control group: (A) HATICE composite z-score (BMI, LDL, and SBP), (B) LDL cholesterol (mmol/L), (C) SBP (mm Hg), (D) BMI (kg/m2), (E) moderate-intense physical activity (hours/week), (F) MEDAS score (range 0-14 points), (G) CAIDE dementia risk score (range 0-15 points), and (H) SCORE-OP (10-year CVD mortality risk). Point estimates are the mean difference in 18-month change compared with the control group. Bars are 95% CIs. Each model was adjusted for baseline age, sex, education, country, physical function, smoking, plans to make lifestyle changes, computer use, and cognition and for baseline score of the outcome of interest if it differed across engagement groups. The HATICE primary outcome measure was a composite score based on the average of 18-month changes in SBP, LDL cholesterol, and BMI z-scores. CAIDE: Cardiovascular Risk Factors, Aging, and Incidence of Dementia; CVD: cardiovascular disease; HATICE: Healthy Ageing Through Internet Counselling in the Elderly; LDL: low-density lipoprotein; MEDAS: Mediterranean Diet Adherence Screener; SCORE-OP: Systematic Coronary Risk Estimation–Older People; SBP: systolic blood pressure.