| Chloroquine and hydroxychloroquine |
Endosome-ACE2 |
Antimalarial drug |
Prevent viral entry via inhibiting viral protein glycosylation and increasing endosomal pH |
86, NCT01067417
|
| Remdesivir, favipiravir, ribavirin, galidesiver |
RdRp |
Ebola, hepatitis C, Marburg virus |
Nucleoside analog enters into the viral RNA chain, causing premature termination |
81, NCT04257656, NCT04319900
|
| Arbidol |
Spike protein-ACE2 |
Influenza antiviral drug |
Prevents viral cell fusion with host cells |
91, NCT04260594, NCT04255017, NCT04252885
|
| Oseltamivir |
Exocytosis of new virus from host cells |
Influenza antiviral drug |
Prevents the secretion of neuraminidase from virus cells, which initiates the release of new virus into host cells |
89, NCT04303299
|
| Famotidine |
PLpro |
Antacid |
Inhibits viral PLpro activity |
92
|
