Figure 7.

A) Commercially available Long Chain AlkylAmine Controlled Pore Glass (LCAA‐CPG) solid support. B) Functionalization of LCAA‐CPG with 5′‐O‐DMT, 3′‐O‐acetyl‐thymidine through the selected hexaethylene glycol spacer. Ac=acetyl; DCC=N,N′‐dicyclohexylcarbodiimide; DEAD=diethyl azodicarboxylate; DMF=N,N‐dimethylformamide; DMT=4,4′‐dimethoxytriphenylmethyl; HOBt=1‐hydroxybenzotriazole; Ph=phenyl; TCA=trichloroacetic acid; THF=tetrahydrofuran. Adapted with permission from Ref. [41] Copyright 2018, Elsevier.