Table 1.
Deduced functions of genes in the lanthomicin biosynthesis gene cluster and protein homologs annotation.
| Gene product | aa | Proposed function | Most similar protein (acc.number) | Identical aa (%) | Homologous gene in xan, arx | Identity/similarity (%) |
|---|---|---|---|---|---|---|
| ORF11 | 62 | Transposase | WP_161968789.1 | 69 | ||
| LtmP1 | 403 | Cytochrome P450 | WP_137814202.1 | 83 | XanO2 | 35/52 |
| LtmO | 620 | Asparagine synthase | WP_137814203.1 | 85 | XanA, Arx5 | 56/67, 44/58 |
| LtmMT1 | 328 | O-methyltransferase | WP_107082228.1 | 76 | Arx6 | 39/58 |
| LtmGT | 354 | Glycosyltransferase | WP_137814140.1 | 76 | XanG, Arx3 | 55/66, 42/58 |
| LtmF1 | 208 | 3-oxoacyl-ACP reductase | WP_137814141.1 | 86 | XanS2, Arx4 | 53/64, 55/66 |
| LtmD1 | 111 | Cyclase | WP_137814142.1 | 87 | XanC3, Arx14 | 67/82, 80/92 |
| LtmD2 | 145 | Cyclase | WP_137814143.1 | 82 | XanC2, Arx15 | 68/79, 70/76 |
| LtmA | 422 | Beta-ketoacyl synthase alpha | WP_137814144.1 | 90 | XanF, Arx16 | 80/88, 78/87 |
| LtmB | 397 | Ketosynthase chain-length factor | WP_137814129.1 | 87 | XanE, Arx17 | 73/80, 76/83 |
| LtmC | 84 | Acyl carrier protein | WP_137814128.1 | 72 | XanD, Arx18 | 40/60, 51/73 |
| LtmD3 | 152 | Cyclase | WP_137814127.1 | 87 | XanC1, Arx19 | 65/76, 70/82 |
| LtmE | 153 | Monooxygenase | WP_049718470.1 | 79 | XanO8, Arx20 | 66/77, 64/73 |
| LtmF2 | 250 | 3-oxoacyl-ACP reductase | WP_137814126.1 | 85 | XanZ3, Arx21 | 65/82, 64/78 |
| LtmG1 | 108 | Monooxygenase | WP_116198857.1 | 86 | XanO7, Arx22 | 58/74, 67/80 |
| LtmG2 | 92 | Monooxygenase | WP_137814125.1 | 84 | XanO6, Arx23 | 62/72, 66/76 |
| LtmH1 | 571 | carboxyl transferase alpha | WP_125308160.1 | 77 | XanB3 | 67/76 |
| LtmH2 | 174 | biotin carboxyl carrier protein | WP_137814199.1 | 76 | XanB2, Arx35 | 53/60, 49/62 |
| LtmH3 | 469 | biotin carboxylase | WP_137814198.1 | 88 | XanB1 | 74/83 |
| LtmR1 | 613 | SARP family transcriptional regulator | WP_198535620.1 | 73 | ||
| LtmI | 540 | FAD-dependent monooxygenase | WP_200827518.1 | 74 | XanO5, Arx10 | 45/58, 41/57 |
| LtmT | 477 | MFS transporter | WP_137814146.1 | 75 | ||
| LtmR2 | 228 | TetR family transcriptional regulator | WP_158879437.1 | 86 | ||
| LtmJ | 149 | Monooxygenase | WP_043782530.1 | 78 | XanO10, Arx25 | 72/81, 63/78 |
| LtmK | 292 | Dehydrogenase | WP_137814130.1 | 79 | XanS1, Arx13 | 53/67, 50/63 |
| LtmD4 | 128 | CurD-like protein | WP_049718476.1 | 86 | XanV, Arx26 | 76/87, 80/89 |
| LtmL | 493 | Peptide permease | KNB50326.1 | 73 | XanQ, Arx28 | 52/68, 49/64 |
| LtmG3 | 541 | FAD-dependent monooxygenase | WP_137814132.1 | 89 | XanO4, Arx30 | 70/82, 64/77 |
| LtmN | 286 | Reductase | WP_137814133.1 | 88 | XanZ1, Arx33 | 57/70, 45/64 |
| LtmG4 | 421 | FAD-dependent monooxygenase | WP_192909516.1 | 83 | XanO4 | 26/39 |
| LtmF3 | 245 | 3-oxoacyl-ACP reductase | WP_137814135.1 | 88 | XanZ4, Arx27 | 65/77, 67/79 |
| LtmMT2 | 336 | Methyltransferase | WP_137814136.1 | 86 | XanM3 | 68/80 |
| LtmD5 | 122 | CurD-like protein | WP_137814137.1 | 83 | XanT, Arx29 | 63/79, 61/75 |
| LtmMT3 | 351 | Methyltransferase | WP_162834049.1 | 80 | XanM3 | 45/62 |
| LtmP2 | 467 | Cytochrome P450 | WP_043782514.1 | 82 | XanO2 | 39/55 |
| ORF47 | 191 | Transcriptional regulator NovG | GCB88085.1 | 70 |