Table 1:
Participant Demographics, Statistical Covariates, and Global Efficiency Metrics according to Mutation Status
| Mutation Status |
|||
|---|---|---|---|
| Variable | Carrier (n = 30) | Noncarrier (n = 38) | P Value |
|
| |||
| Age (y) | 34 ± 10 (20–57) | 37 ± 10 (19–61) | .27 |
| Estimated years to symptom onset | −13.8 ± 9.0 (−28 to 3) | −9.4 ± 11.8 (−29 to 16) | .10 |
| Sex* | .93 | ||
| M | 13 | 18 | |
| F | 17 | 20 | |
| Education (y) | 15.7 ± 3.4 (11–24) | 15.1 ± 2.6 (10–21) | .41 |
| Mini-Mental State Examination score | 30.0 ± 1.5 (24–30) | 29.2 ± 1.2 (25–30) | .46 |
| Wechsler Memory Scale-Revised | |||
| Logical memory IA-immediate | 14.0 ± 4.2 (4–22) | 14.3 ± 3.9 (5–24) | .73 |
| Logical memory IIA-delayed | 12.6 ± 4.8 (2–21) | 13.4 ± 3.9 (6–24) | .44 |
| Word list recall-immediate | 5.7 ± 1.9 (2–12) | 5.9 ± 2.2 (1–11) | .63 |
| Word list recall-delayed | 3.1 ± 2.1 (0–9) | 3.2 ± 2.4 (0–9) | .81 |
| Apolipoprotein E4 allele status* | >.99 | ||
| Positive | 8 | 9 | |
| Negative | 22 | 29 | |
| Global cortical PiB amyloid PET SUVr | 1.58 ± 0.65 (0.88–2.39) | 1.04 ± 0.06 (0.92–1.14) | <.001 |
| Normalized cerebral white matter volume (% intracranial volume) | 30.5 ± 2.0 (27.9–34.1) | 30.3 ± 2.0 (26.7–34.8) | .54 |
Note.—Unless otherwise specified, data are means ± standard deviations, with ranges in parentheses. P values are from analysis of variance or χ2 test of each variable versus mutation status, as appropriate. PiB = Pittsburgh compound B, SUVr = standardized uptake value ratio.
*
Data are numbers of participants.