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. 2022 May 10;9:875208. doi: 10.3389/fmolb.2022.875208

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Copyright © 2022 Makgoo, Mosebi and Mbita.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) TP53 mRNA transcripts, coding exons (blue), noncoding exons (yellow) and alternative exons (i). Although there are 15 transcripts encoded in the TP53 gene, only 9 transcripts are often presented because some code for the same protein isoforms. (B) There are 12 different p53 isoforms, containing various combination of the different domains, which include the transactivation domain 1 (TAD1), the transactivation domain 2 (TAD2), the DNA binding domain (DBD), the proline-rich domain (PRD), the oligomerization domain (OD), the hinge domain (HD), and the negative regulation domain (α). Adapted from Anbarasan and Bourdon (2019).