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MDM2 regulates the stability of TP53, thus, influencing its role in cell homeostasis. Negative regulators of TP53 such as RBBP6 can interact with MDM2 and facilitate the ubiquitination and degradation of TP53 by MDM2. Overexpression of MDM2 significantly delays DNA repair, resulting in damage persisting for longer thus promoting genome instability, which leads to cancer development.
