Table 2. Average Pharmacokinetic Parameters of Pentarlandir UPPTA in Plasma in Each Animal Group.
| condition/dosage | Tmax (h) | Cmax(μM) | T1/2 (h) | AUC0-t (μM·h) | AUC0-∞ (μM·h) |
|---|---|---|---|---|---|
| fed, single dose/1000 mg/kg | 3.40 ± 1.82 | 0.91 ± 0.35 | 3.90 ± 2.23 | 4.84 ± 1.92 | 6.73 ± 2.91 |
| fasting, single dose/350 mg/kg | 5.33 ± 0.82 | 0.69 ± 0.57 | 3.48 ± 2.44 | 2.39 ± 1.31 | 4.10 ± 1.73 |
| fasting, single dose/750 mg/kg | 2.60 ± 1.82 | 2.12 ± 0.65 | 2.58 ± 1.17 | 13.82 ± 7.61 | 13.94 ± 7.65 |
| fasting, single dose/1000 mg/kg | 3.71 ± 1.60 | 4.59 ± 1.36 | 2.74 ± 1.63 | 26.06 ± 9.58 | 30.16 ± 13.24 |
| fasting, 14-day repeated dose/1000 mg/kg/day | 4.83 ± 0.98 | 3.62 ± 1.74 | 6.01 ± 0.78 | 34.13 ± 11.39 | 36.73 ± 12.20 |