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. 2022 May 10;9:783121. doi: 10.3389/fmed.2022.783121

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Copyright © 2022 Li, Kong, Bi and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intestinal barrier function was evaluated in mice and humans in the context of METH treatment. (A) Intestinal mucosal injury, intestinal wall permeability, and bacterial translocation are assessed by determining the serum levels of diamine oxidase (DAO), D-lactic acid (DLA), and endotoxin (ET) in Meth-dependent patients (MDPs). Abnormal levels of all these indicators reflect intestinal barrier dysfunction. (B) Intestinal epithelial cells of methamphetamine-treated mice are evaluated for intestinal barrier function by apoptosis, TEER, proinflammatory factors, and HE staining. Abnormal levels of all these indicators reflect intestinal barrier dysfunction.