Table 2.
Number of adverse effects reported as severe and most frequently reported adverse effects according to gender identity and gender role subgroups.
| Total | Gender identity subgroups | Gender role subgroups | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n = 1,343 |
Men n = 199 |
Women n = 1,119 | p -value* | Feminine (F) Describe themselves as tender and sensitive to others n = 270 |
Masculine (M) Describe themselves as athletic, having leadership, and being self-confident n = 233 |
Androgynous (A) Scored high on all these traits n = 368 |
Undifferentiated (U) n = 322 |
p -value** | |
| Number of adverse effects reported as severe—mean ± SD | 1.56 ± 2.10 | 1.42 ± 1.96 | 1.57 ± 2.12 | 0.5850 | 2.07 ± 2.42 | 1.09 ± 1.73 | 1.46 ± 2.04 | 1.45 ± 2.05 |
<0.0001 Post-hoc differences: F-M, F-A, F-U |
| Proportion of participants without adverse effects—n (%) | 134 (10.10) | 13 (6.53) | 120 (10.88) | 0.0624 | 21 (7.87) | 29 (12.45) | 49 (13.39) | 24 (7.55) |
0.0270 Post-hoc differences: none according to conservative tests |
| Most frequently reported adverse effects—n (%) | |||||||||
| Fatigue | 990 (76.45) | 159 (81.12) | 810 (75.42) | 0.0842 | 216 (82.76) | 170 (75.56) | 257 (71.79) | 239 (76.85) |
0.0170 Post-hoc differences: F-A |
| Dry mouth | 868 (66.77) | 135 (69.23) | 715 (66.20) | 0.4092 | 197 (74.62) | 147 (64.19) | 221 (61.73) | 199 (64.40) |
0.0064 Post-hoc differences: F-A, F-U |
| Drowsiness | 813 (62.93) | 130 (66.67) | 667 (62.22) | 0.2371 | 178 (68.20) | 142 (62.01) | 211 (58.94) | 196 (64.05) | 0.1217 |
| Decreased sex drive | 779 (61.05) | 132 (68.75) | 629 (59.34) | 0.0140 | 179 (68.58) | 121 (54.02) | 200 (56.82) | 194 (63.19) |
0.0029 Post-hoc differences: F-M, F-A |
| Most frequent adverse effects reported as severe—n (%) | |||||||||
| Fatigue | 357 (27.57) | 43 (21.94) | 306 (28.49) | 0.0588 | 95 (36.40) | 46 (20.44) | 101 (28.21) | 74 (23.79) |
0.0004 Post-hoc differences: F-M, F-U |
| Decreased sex drive | 303 (23.75) | 51 (26.56) | 244 (23.02) | 0.2871 | 76 (29.12) | 43 (19.20) | 67 (19.03) | 87 (28.34) |
0.0022 Post-hoc differences: F-A, A-U |
| Dry mouth | 221 (17.00) | 29 (14.87) | 187 (17.31) | 0.4026 | 62 (23.48) | 22 (9.61) | 54 (15.08) | 48 (15.53) |
0.0004 Post-hoc differences: F-M, F-A |
| Insomnia | 197 (15.59) | 33 (17.28) | 158 (15.06) | 0.4353 | 43 (16.80) | 19 (8.56) | 63 (18.00) | 39 (12.96) |
0.0096 Post-hoc differences: F-M, A-M |
*
Chi-square tests or Wilcoxon rank-sum tests.
**
Chi-square tests or Kruskal-Wallis tests with Tukey style multiple comparisons of proportions or Dwass-Steel-Critchlow-Fligner tests for post-hoc pairwise analyses.
Proportion of missing data across presented variable ranges between 1.19 and 5.88%.
P-values < 0.05 are reported in bold.
SD, Standard deviation.