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. 2022 May 10;13:829406. doi: 10.3389/fimmu.2022.829406

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Copyright © 2022 Lellouch, Andrews, Saviane, Ng, Schol, Goutard, Gama, Rosales, Colvin, Lantieri, Randolph, Benichou and Cetrulo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sub-analysis of T cell subsets in multi-lineage mixed chimerism. Post-transplantation, as bone marrow reconstitution progresses, the percentage of donor (PAA+) and recipient (PAA-) T cells approaches equilibrium at around POD100, remained stable and varied between 50 to 70% of donor T cells to experimental endpoint (A). The population of double negative (CD4-/CD8-) T cells increase from around POD 50 onwards (following cessation of FK506) and remained at about 20 to 40% of overall CD3+ T cell to experimental endpoint (B). The results shown were obtained in one tolerant swine and are representative of all tolerant swine tested individually.