Table 1.
Description of transplant characteristics.
| Animal | Sex | Weight(kg, POD 0) | TBI (cGy) | TI (cGy) | Steroid | Costim Blockade (CTLA-4 Ig) | Anti-IL6R | Calcineurin Inhibitor | BM dose(cells x109/kg) | Immunosuppression withdrawal (POD) | Multilineage Chimerism | Study Outcomes |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R1 | M | 23.8 | 300 | 700 | None | Yes | None | Tacrolimus | 1.0 | Not done, see outcomes | – | Early study removal, IPS, respiratory distress |
| R2 | M | 25.0 | 300 | 700 | None | Yes | None | Tacrolimus | 1.0 | Not done, see outcomes | – | Early study removal, IPS, respiratory distress |
| R3 | M | 21.9 | 300 | 700 | Yes | Yes | Tocilizumab | Tacrolimus | 1.0 | 45 | Yes | Immunosuppression free VCA tolerance |
| R4 | M | 10.7 | 300 | 700 | Yes | Yes | Tocilizumab | Tacrolimus | 1.0 | 45 | Yes | Immunosuppression free VCA tolerance |
| R5 | M | 19.0 | 300 | 700 | Yes | Yes | Tocilizumab | Tacrolimus | 1.0 | 45 | Yes | Immunosuppression free VCA tolerance |
| R6 | M | 38.0 | None | None | None | None | None | None | None | – | – | VCA rejection |
| R7 | M | 38.0 | None | None | None | None | None | None | None | – | – | VCA rejection |
Total body irradiation (TBI), thymic irradiation (TI), centi-gray (cGy), bone marrow (BM), idiopathic pulmonary syndrome (IPS).