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Validation by sequencing defined sample mixtures. Observed (mean +/− s.e. across 27 replicates) vs expected variant allele frequency (VAF) for repeated smMIPS sequencing of a defined control mixture of gDNAs from five cell lines, across 152 polymorphic sites. Overall Pearson’s correlation r = 0.998, and r = 0.847 and r = 0.997 for variants with expected VAF ≤2 and > 2%, respectively
